منابع مشابه
Protein Degradation in Cultured Cells
The degradation of cellular proteins in fibroblasts, both those of rapid and those of slow turnover rates, was inhibited by low concentrations of chloroquine or neutral red in the medium. Cells inhibited by chloroquine can be inhibited further by fluoride. Chloroquine was taken up by the fibroblasts and the concentration in the cells reached several hundred times that in the medium. Isopycnic f...
متن کاملHyperthermia stimulates energy-proteasome-dependent protein degradation in cultured myotubes.
Previous studies suggest that elevated temperature stimulates protein degradation in skeletal muscle, but the intracellular mechanisms are not fully understood. We tested the role of different proteolytic pathways in temperature-dependent degradation of long- and short-lived proteins in cultured L6 myotubes. When cells were cultured at different temperatures from 37 to 43 degrees C, the degrada...
متن کاملPROTEIN DEGRADATION IN CULTURED CELLS II. The Uptake of Chloroquine by Rat Fibroblasts and the Inhibition of Cellular Protein Degradation and Cathepsin Bx
The degradat ion of cellular proteins in fibroblasts, both those of rapid and those of slow turnover rates, was inhibited by low concentrat ions of chloroquine or neutral red in the medium. Cells inhibited by chloroquine can be inhibited further by fluoride. Chloroquine was taken up by the fibroblasts and the concentra t ion in the cells reached several hundred times that in the medium. Isopycn...
متن کاملRuminal Protein Degradation and Estimation of Rumen Microbial Protein Production
Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...
متن کاملRuminal Protein Degradation and Estimation of Rumen Microbial Protein Production
Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1974
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.63.2.430